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Invitrogen
Thrombospondin 1 Monoclonal Antibody (A65M)
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Product Details
CSI 002-65-02
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Published species
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
A65M
Immunogen
Extracellular matrix materila fom cultured bovine corneal endothelial cells
Conjugate
Form
Liquid
Concentration
0.91 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
15mM sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2271659
Product Specific Information
CSI 002-65-02 is highly specific for the low-calcium conformation of thrombospondin. There is no evidence for
cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin). CSI 002-65-02 cross-reacts with human thrombospondin. Other species have not been tested.
CSI 002-65-02 has been successfully used in ELISA, Immunohistochemistry and Immunoprecipitation procedures.
CSI 002-65 can also be used to probe for the low-calcium conformation of thrombospondin.
The CSI 002-65-02 epitope is only present in thrombospondin prepared with low levels of calcium.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Glycoprotein G; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1
Gene Aliases: BOS_10716; THBS; THBS-1; THBS1; TSP; TSP-1; TSP1
UniProt ID: (Human) P07996, (Bovine) Q28178
Entrez Gene ID: (Human) 7057, (Bovine) 281530
phosphatidylserine binding
glycoprotein binding
fibronectin binding
integrin binding
calcium ion binding
protein binding
heparin binding
fibroblast growth factor binding
low-density lipoprotein particle binding
identical protein binding
laminin binding
proteoglycan binding
transforming growth factor beta binding
fibrinogen binding
collagen V binding
activation of MAPK activity
response to hypoxia
negative regulation of endothelial cell proliferation
negative regulation of cell-matrix adhesion
sprouting angiogenesis
chronic inflammatory response
platelet degranulation
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
inflammatory response
immune response
response to unfolded protein
cell cycle arrest
cell adhesion
response to glucose
positive regulation of endothelial cell migration
negative regulation of endothelial cell migration
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of nitric oxide mediated signal transduction
negative regulation of cGMP-mediated signaling
negative regulation of plasminogen activation
positive regulation of macrophage chemotaxis
positive regulation of fibroblast migration
cell migration
negative regulation of angiogenesis
peptide cross-linking
positive regulation of blood coagulation
extracellular matrix organization
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of cGMP metabolic process
response to magnesium ion
response to progesterone
negative regulation of interleukin-12 production
positive regulation of transforming growth factor beta1 production
cellular response to heat
response to endoplasmic reticulum stress
protein O-linked fucosylation
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of phosphorylation
response to drug
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
engulfment of apoptotic cell
positive regulation of translation
positive regulation of angiogenesis
behavioral response to pain
positive regulation of chemotaxis
response to calcium ion
negative regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of endothelial cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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